Oestrogen Treatments/

Everything you need to know about Estradot

Estradot is a form of oestrogen replacement therapy used as part of Hormone Replacement Therapy (HRT). It is a transdermal patch, meaning it delivers oestrogen through the skin rather than orally.

If you are considering Estradot as part of your HRT plan, here is what you need to know about how to use it, its benefits, and possible side effects.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Doctor

iconReviewed: 19/02/2025 Published: 21/02/2025
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The basics

Key information about Estradot

4 tips to help you

How and where to apply Estradot?

  • 1

    Directly to skin

    Apply directly to skin, replacing twice per week. Apply the patch to a hairless area.

  • 2

    Apply to the lower abdomen or buttocks

    It is important the patch is applied below the waist

  • 3

    Avoid areas of skin irritation or tight clothing.

    Do not apply creams or gels before the patch, as this can affect stickiness

  • 4

    Change application sites regularly

    Rotate application sites to prevent skin irritation.

Benefits of Estradot

Replacing oestrogen with Estradot can bring many benefits, and have an impact on all 40 symptoms of menopause.

  • Supports bone health - reduces the risk of osteoporosis
  • Provides a steady release of oestrogen - helping to maintain stable hormone levels
  • Bypasses digestion - making it a gentler option for those who experience stomach issues with oral HRT
  • Lower risk of blood clots - compared to oral oestrogen
Book your first consultation

Book a consultation with a menopause specialist, or view our different plans to learn more about what we offer.

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Estradot explained

Dr. Laura Cawley and Dr. Liz Andrew explain Estradot on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.

Estradot is available on our All-in-one plans

Our plans cover appointments, medication and on-going support

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All-in-one plans

Conveniently access care online, from either a doctor or menopause nurse


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Initial appointment online with your specialist (45 minutes)
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Prescribed medication (up to £90 is covered, every 3 months)
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Follow-up appointments with the same specialist every 3 months (30 minutes)
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Support from a personal care coordinator
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Unlimited mentoring sessions
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Flexible to cancel every 3 months
Doctor all-in-one plan
£89 per month
Nurse all-in-one plan
£49 per month
Estradot with Menopause Care

If you are not a patient with us, but you would like this medication, you will need to book to see one of our expert doctors who will work with you to create a treatment plan.

Estradot side effects

Common side effects can include:

  • Skin irritation on the site which the patch is applied
  • Breast tenderness or pain
  • Bloating
  • Abdominal pain
  • Headaches
  • Mood changes

Estradot dosages explained

Everything you need to know about Estradot dosages
25mcg patch
Dosage level.

Provides 25mcg of estradiol. This is considered a low dose.

How often should you change your patch?

Every 3-4 days

50mcg patch
Dosage level

Provides 50mcg of estradiol. This is considered a moderate dose.

How often should you change your patch?

Every 3-4 days

75mcg patch
Dosage level

Provides 75mcg of estradiol. This is considered a moderate dose.

How often should you change your patch?

Every 3-4 days

100mcg patch
Dosage level

Provides 100mcg of estradiol. Considered a high dose

How often should you change your patch?

Every 3-4 days

Additional information

As this is a higher dose of oestrogen, higher doses of progesterone are needed, if you still have a womb.

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Dr. Liz Andrew
Your dosage level of Estradot can vary depending on the individual. This should be explained clearly by your doctor before starting medication and also throughout your treatment if you are making any adjustments.
Book your first consultation

Book a consultation with a menopause specialist, or view our different plans to learn more about what we offer.

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Not sure how we can help?

Book a complementary discovery call with our patient expert who can answer any questions about our services