Everything you need to know about Evorel Sequi patches
Everything you need to know about Evorel Sequi patches
Evorel Sequi is a form of oestrogen and progestogen replacement therapy used as part of Hormone Replacement Therapy (HRT). It is a sequential HRT patch, meaning it provides oestrogen-only patches for part of the cycle, followed by combined oestrogen and progestogen patches. This mimics the natural menstrual cycle and is designed for women who are perimenopausal.

Medically reviewed by Dr. Liz Andrew
BMS Accredited Doctor

Key Information About Evorel Sequi
How and Where to Apply Evorel Sequi
- 1
Apply directly to the skin
Replace the patch twice per week.
- 2
Apply to the lower abdomen or buttocks
IT is important to place the patch below the waist
- 3
Avoid areas of irritated skin or tight clothing
Do not apply creams or gels before the patch, as this can affect its adhesion
- 4
Change where you put the patch
Rotating the application site prevents skin irritation

Benefits of Evorel Sequi
- The Estradiol in evorel sequi patches can help to:
- Relieve any of the 40 menopause symptoms you might have by replacing your natural oestrogen
- Supports bone health – reduces the risk of osteoporosis
- Provides a steady release of oestrogen – helping to maintain stable hormone levels
- Bypasses digestion – making it a gentler option for those who experience stomach issues with oral HRT
- Lower risk of blood clots – compared to oral oestrogen (tablets)
The progestogen as part of the combined patches helps protect the lining of the womb.

Evorel Sequi explained
Dr. Laura Cawley and Dr. Liz Andrew explain combined patches on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.
Evorel Sequi is available on our Personalised plan
Our plans cover appointments, medication and on-going support

Conveniently access care online, from either a doctor or menopause nurse
If you are not a patient with us, but you would like this medication, you will need to book to see one of our expert doctors who will work with you to create a treatment plan.

Side effects of Evorel Sequi
Common side effects:
- Skin irritation where the patch is applied
- Breast tenderness or pain
- Bloating
- Abdominal discomfort
- Headaches
- Mood changes







Helpful resources
Explore menopause guidance from our specialists

Signs HRT is not working for you
Understanding how HRT works and what to expect can help manage expectations when you start treatment.

Oestrogen replacement
There are many different types of oestrogen replacement and understanding your options can help you to make the best choice for your health and well-being.

Bio identical vs body identical hormone replacement therapy
This guide looks at the differences between body identical HRT and bioidentical HRT.

HRT and breast cancer
You may be ready to explore treatment options but be worried about the risks of taking hormone-based medications. Read our article about HRT and breast cancer to understand more.
