Everything you need to know about Evorel Sequi patches

Evorel Sequi is a form of oestrogen and progestogen replacement therapy used as part of Hormone Replacement Therapy (HRT). It is a sequential HRT patch, meaning it provides oestrogen-only patches for part of the cycle, followed by combined oestrogen and progestogen patches. This mimics the natural menstrual cycle and is designed for women who are perimenopausal.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Doctor

iconReviewed: 20/02/2025 Published: 19/03/2025
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The basics

Key Information About Evorel Sequi

4 tips to help you

How and Where to Apply Evorel Sequi

  • 1

    Apply directly to the skin

    Replace the patch twice per week.

  • 2

    Apply to the lower abdomen or buttocks

    IT is important to place the patch below the waist

  • 3

    Avoid areas of irritated skin or tight clothing

    Do not apply creams or gels before the patch, as this can affect its adhesion

  • 4

    Change where you put the patch

    Rotating the application site prevents skin irritation

Benefits of Evorel Sequi

  • The Estradiol in evorel sequi patches can help to:
  • Relieve any of the 40 menopause symptoms you might have by replacing your natural oestrogen
  • Supports bone health – reduces the risk of osteoporosis
  • Provides a steady release of oestrogen – helping to maintain stable hormone levels
  • Bypasses digestion – making it a gentler option for those who experience stomach issues with oral HRT
  • Lower risk of blood clots – compared to oral oestrogen (tablets)

The progestogen as part of the combined patches helps protect the lining of the womb.

Book your first consultation

Book a consultation with a menopause specialist, or view our different plans to learn more about what we offer.

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Evorel Sequi explained

Dr. Laura Cawley and Dr. Liz Andrew explain combined patches on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.

Evorel Sequi is available on our Personalised plan

Our plans cover appointments, medication and on-going support

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Personalised plan

Conveniently access care online, from either a doctor or menopause nurse


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Initial appointment online with your specialist (45 minutes)
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Prescribed medication (up to £90 is covered, every 3 months)
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Follow-up appointments with the same specialist every 3 months (30 minutes)
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Responsive messaging support with a clinician, available 5 days a week
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Unlimited mentoring sessions
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Flexible to cancel every 3 months
Doctor all-in-one plan
£89 per month
Evorel Sequi with Menopause Care

If you are not a patient with us, but you would like this medication, you will need to book to see one of our expert doctors who will work with you to create a treatment plan.

Side effects of Evorel Sequi

Common side effects:

  • Skin irritation where the patch is applied
  • Breast tenderness or pain
  • Bloating
  • Abdominal discomfort
  • Headaches
  • Mood changes
Book your first consultation

Book a consultation with a menopause specialist, or view our different plans to learn more about what we offer.

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Not sure how we can help?

Book a complementary discovery call with our patient expert who can answer any questions about our services