Oestrogen Treatments/

Everything you need to know about Lenzetto

Lenzetto is a form of oestrogen replacement therapy used as part of Hormone Replacement Therapy (HRT). It is a transdermal spray, meaning it delivers oestrogen through the skin, rather than being taken orally.

If you are considering Lenzetto as part of your HRT plan, here is what you need to know about how to use it, its benefits, and possible side effects.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Doctor

iconReviewed: 24/02/2025 Published: 25/02/2025
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The basics

Key information about Lenzetto

4 tips to help you

How and where to use Lenzetto?

  • 1

    Apply directly to skin on the inner forearm or inner thigh

    Choose clean, dry, and unbroken skin. Do not apply to the face, breasts and genitals.

  • 2

    Press the pump once

    This applies a single measured dose of the spray.

  • 3

    Allow the spray to dry completely

    Make sure you are completely dry before putting on your clothes.

  • 4

    Do not apply any other products

    Do not wash or apply lotions, creams, or sunscreen for at least 1 hour after application.

Benefits of Lenzetto

Replacing oestrogen with Lenzetto can bring many benefits, and have an impact on all 40 symptoms of menopause.

  • Relieves menopause symptoms
  • Supports bone health - reduces the risk of osteoporosis
  • Bypasses digestion - making it a gentler option for those who experience stomach issues with oral HRT
  • Lower risk of blood clots - compared to oral oestrogen
  • Easy & quick application - Lenzetto spray dries faster than oestrogen gels. There is less skin residue like oestrogen gels and it is good for women who dislike patches or gels.
  • Discreet & portable - it is a small spray bottle.
Book your first consultation

Book a consultation with a menopause specialist, or view our different plans to learn more about what we offer.

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Lenzetto explained

Dr. Liz Andrew explains Lenzetto on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.

Lenzetto is available on our All-in-one plans

Our plans cover appointments, medication and on-going support

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All-in-one plans

Conveniently access care online, from either a doctor or menopause nurse


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Initial appointment online with your specialist (45 minutes)
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Prescribed medication (up to £90 is covered, every 3 months)
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Follow-up appointments with the same specialist every 3 months (30 minutes)
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Support from a personal care coordinator
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Unlimited mentoring sessions
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Flexible to cancel every 3 months
Doctor all-in-one plan
£89 per month
Nurse all-in-one plan
£49 per month
Lenzetto with Menopause Care

If you are not a patient with us, but you would like this medication, you will need to book to see one of our expert doctors who will work with you to create a treatment plan.

Side effects of Lenzetto

Common side effects of Lenzetto can include:

  • Breast tenderness
  • Headaches
  • Nausea
  • Bloating
  • Changes in mood
  • Skin irritation at the application site

Less Common Side Effects of Lenzetto are:

  • Dizziness
  • Fluid retention
  • Leg cramps
  • Changes in libido

Lenzetto dosages explained

Everything you need to know about Lenzetto dosages
1 spray of Lenzetto
Dosage level

Provides 1.53mg of estradiol. This is considered a very low dose.

Application frequency

Applied daily

2 sprays of Lenzetto
Dosage level

Provides 3.06mg of estradiol. This is considered a low dose.

Application frequency

Applied daily

3 sprays of Lenzetto
Dosage level

Provides 4.59mg of estradiol. This is considered a standard dose.

Application frequency

Applied daily

4-5 sprays of Lenzetto
Dosage level

Provides 6.12 to 7.65mg estradiol. This is considered a moderate dose.

Application frequency

Applied daily

6 sprays of Lenzetto
Dosage level

Provides 9.18mg estradiol. This is considered a high dose.

Application frequency

Applied daily

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Dr. Liz Andrew
Your dosage level of Lenzetto can vary depending on the individual. This should be explained clearly by your doctor before starting medication and also throughout your treatment if you are making any adjustments.
Book your first consultation

Book a consultation with a menopause specialist, or view our different plans to learn more about what we offer.

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Not sure how we can help?

Book a complementary discovery call with our patient expert who can answer any questions about our services